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Ozempic and Wegovy are two brand names for Semaglutide. This is a long-lasting GLP-1 receptor agonist that can be given via subcutaneous injection once a week.

It has demonstrated efficacy in weight reduction in studies with patients both with and without Type 2 Diabetes. Ozempic was originally created to manage Type 2 Diabetes, as it aids in reducing blood sugar levels.

However, it resulted in an additional advantage of weight loss, which subsequently led people without Type 2 Diabetes to start requesting Ozempic for weight reduction.

Remember that only the injectable version, Wegovy, is authorized for obesity treatment (the oral form is not).

Semglutide has been demonstrated to lower cardiovascular (CV) risk factors in individuals with pre-existing CV conditions in certain CV outcome studies.

How Does Ozempic Function for Weight Loss?

Previously regarded as overweight or obese, the approach involves: administering Ozempic injections at the highest dose (2.4 mg weekly) to facilitate optimal weight reduction.

However, patients should not begin with the highest dose immediately, since some may not tolerate it and could experience side effects such as nausea or vomiting. For this reason, a slow escalation of the dose is advised.

The mechanism of Semaglutide (Ozempic and Wegovy) in aiding weight loss is quite fascinating. GLP-1 is a key incretin hormone present in humans. In other words, it boosts insulin secretion, blocks glucagon release, and diminishes hepatic gluconeogenesis.

Semaglutide additionally leads to delayed gastric emptying, decreased appetite, and reduced energy intake, contributing to its positive effects on weight loss. It slows down the speed at which your stomach releases food following a meal (gastric emptying). The more time gastric emptying takes, the longer food remains in your stomach, causing you to feel satisfied for a greater duration.

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